Chemokines are powerful disease fighting capability molecules regarded as important in lymph node function and formation during development. The 12-chemokine gene expression signature was discovered to remarkably predict the presence of microscopic lymph node-like structures within some melanomas and was also connected with better overall survival of the patients. The researchers speculate that the lymph nodal structures they recognized are energetic and playing an important positive function in a self-elicited anti-tumor response – initially locally and systemically. In addition they anticipate that their findings in melanoma might lengthen to various other solid tumors, such as for example those of colorectal, lung and ovarian origin.We are also motivated by our preliminary pre-medical data using siRNAs targeting TTR for the treatment of ocular amyloidosis. Expression of mutant TTR in retinal cells can lead to blindness in ATTR individuals, and an intraocular injection approach with this TTR-specific siRNA could be advanced as a primary RNAi therapeutic strategy. The brand new pre-clinical studies, performed in collaboration with Dr. Maria Saraiva at the Institute for Cellular and Molecular Biology in Portugal, utilized a transgenic mouse model where the mutant individual V30M TTR gene can be over-expressed. Specifically, the brand new data demonstrated that administration of ALN-TTR01 in mature transgenic mice resulted in the regression of existing pathogenic mutant human V30M TTR deposits in cells, including: dorsal root ganglia, sciatic nerve, tummy, and intestines.