The National Institute of Allergy and Infectious Illnesses and the U.S. Agency for International Advancement reviewed the analysis protocol. The trial was monitored by the Nationwide Institute of Allergy and Infectious Illnesses and the U.S. Army Medical Material Development Activity. An independent data and safety monitoring board and a local safety monitor had been appointed by the Nationwide Institute of Allergy and Infectious Diseases. The trial was carried out in compliance with the analysis protocol, the International Conference on Harmonization of Great Clinical Practices, the Declaration of Helsinki, and regulatory requirements of Mali. Program staff from the National Institute of Allergy and Infectious Illnesses contributed to the analysis style but played no part in the collection, analysis, or interpretation of the data, the writing of the manuscript, or your choice to post it for publication, all of which were done by the authors.All sufferers had been counseled on the components of the Therapeutic CHANGES IN LIFESTYLE diet, as reported by the Adult Treatment Panel III of the National Cholesterol Education Program.11 Based on the screening LDL cholesterol rate, previous use of statin therapy, and cardiovascular risk , we assigned all sufferers to one of four lipid-lowering regimens: diet alone, diet plan with 10 mg of atorvastatin daily, diet plan with 80 mg of atorvastatin daily, or diet with 80 mg of atorvastatin plus 10 mg of ezetimibe daily. At the conclusion of the first 4 weeks of the run-in period, eligibility for randomization was based on a fasting LDL cholesterol level of 75 mg per deciliter or higher, as dependant on the central laboratory .