The iUni G2 trial will enroll adult patients whose doctors have recommended a unicompartmental knee implant because of osteoarthritis. Potential participants will get a baseline evaluation to determine their eligibility for the study and also questionnaires about symptoms and standard of living. Those determined ineligible could have the opportunity to discuss alternatives with their doctors. Those who are chosen for participation shall undergo medical procedures to implant a custom iUni G2, and then be asked to go back to the clinic for follow-up assessments, including questionnaires and X-rays, for a period of five years.Brooks, Ph.D., of NIAAA and Miral Dizdaroglu, Ph.D., of NIST, examined acetaldehyde’s reaction with polyamines, little molecules within all cells. Polyamines are often considered ‘good men,’ because they have already been shown to secure DNA from oxidative harm, says Dr. Brooks. Yet the researchers found the polyamines facilitated the transformation of acetaldehyde into crotonaldehyde , an environmental pollutant that is shown to cause cancers in animals. This chemical in turn altered DNA, generating an irregular, mutagenic DNA bottom called a Cr-PdG adduct. Dr. Brooks says, We figured polyamines stimulated the formation of Cr-PdG adducts from acetaldehyde, which might provide a mechanism to explain how alcohol consumption increases the risk of some types of malignancy.