Acacia Pharma initiates two pivotal Stage 3 research of APD421 in prevention of PONV Acacia Pharma, a pharmaceutical organization specialising in the development of medicines for supportive treatment, announces the initiation of two pivotal Stage 3 research of APD421 in the prevention of post-operative nausea & vomiting www.med-drugs.com . PONV remains a clinically significant problem in patients undergoing major surgery, despite the option of a variety of anti-emetic medicines. The Phase 3 research are taking place in 19 main centres in France, Germany and the USA. They will recruit a total of 680 surgical patients at moderate to high risk of suffering PONV . The trials compare the perfect dose of APD421 against placebo, the primary endpoint being no vomiting or retching and no requirement of anti-emetic rescue medication in the first a day after surgery.
So where’s the calcium supplement in this?Too much calcium is as bad as inadequate just! Calcium overload complications include stroke, pain, fatigue, tumor and – – brittle bones. The advantages of calcium max out at 750 mg a full day. People with diets low in calcium actually have higher absorption of calcium than those on high-calcium diets or supplements. The Institute of Medication recommended daily allowance for calcium from a combined mix of diet plus health supplements was arranged at 1000 mg a time for women until age 50 years and 1200 mg a day time for women over 50 years old. A lot of women get around 700 mg a time from dietary sources only and require no more than an additional 500-600 mg a day from supplements.