Rachel B. Jones, M Get more information .R.C.P., M.D., Jan Willem Cohen Tervaert, M.D., Ph.D., Thomas Hauser, M.D., Raashid Luqmani, D.M., F.R.C.P., F.R.C.P., Matthew D. Morgan, M.R.C.P., Ph.D., Chen Au Peh, F.R.A.C.P., Ph.D., Caroline O. Savage, Ph.D., F.R.C.P., F.Med.Sci.D., Ph.D., Vladimir Tesar, M.D., Ph.D., Pieter van Paassen, M.D., Ph.D., Dorothy Walsh, B.S.C.N., Michael Walsh, M.D., F.R.C.P., Kerstin Westman, M.D., Ph.D., and David R.W. Jayne, M.D., F.R.C.P. Renal involvement happens in 70 percent of affected patients and is definitely manifested as rapidly progressive glomerulonephritis with pauci-immune necrotizing, crescentic glomerulonephritis on biopsy.
Montine and his colleagues believe that, and are studying in greater detail now, this small vessel harm is the cumulative aftereffect of multiple small strokes due to hypertension and diabetes, strokes so small that the individual experiences no sensation or problems until the cumulative effect reaches a tipping point. This may be good news, says Dr. Montine. At a time when prevention and treatment for Alzheimer’s remain investigational, options for preventing problems of hypertension and diabetes are available currently. These findings have become not the same as both conventional wisdom and from those of all autopsy studies of brain maturing and dementia, says Dr.