Lymphomas often B-cells, B-cells, the same cells that produce antibodies to fight infections originate. AB cell can become cancerous if a gene, such as c-myc leaps to another section of the DNA , fuses it with known, and somehow about on. Scientists have wondered for years how this oncogenic activation occurs in particular what component in the IgH region activates c-myc http://aciphex.net . The new study, in the 10th December issue of of the journal Nature was published identify this regulatory component a far-reaching the first time researchers to understand how this movement of genes, or chromosomal translocation, can hijack a B cell operation badly enough to lead to cancer. – IgH-to – myc translocation is the classic example of activation of an oncogene in cancer, says Frederick Alt, scientific director of PCMM / IDI and senior author of of the study. But no one really understood how it works. – Aberrant DNA translocations, during two different phases of a B-cell development may occur: during a process as VDJ recombination fight when a precursor-B-cells of an antibody against a particular pathogen, creates or during class switch recombination known as a mature B cell gives its antibody a different strategy to fight infection . Based on their previous research, Alt and his colleagues decided to focus on one part of the region known as IgH IgH 3 ‘ regulatory region . They had already shown IgH3’RR that a far-reaching gene regulator, the transcription of adjacent genes in the IgH region during class switch recombination, may be increased.
A new target for lymphoma therapyResearchers at the Program in Cellular and Molecular Medicine and the Immune Disease Institute at Children’s Hospital Boston between a common between a common mutation that and and a distant gene regulator the enhances its activity. Discovery of this relationship could be the medication for B-cell lymphomas, including Burkitt’s lymphoma, an aggressive childhood cancer, as well as multiple myeloma and other blood cancers result.
‘At the same time we live in one period when is it really and which widespread public concern animal welfare for farmed animals animal disease threats old and the new[ as bluetongue, bird flu and swine flu] and foods security. ‘.