‘It has been extremely encouraging to observe so many signals of efficacy in this trial, specifically because of the study population. They are end-stage cancer patients, who have already been treated with and become refractory to multiple lines of standard therapy. It has additionally been encouraging to see signals of ACE-041 activity in an array of tumour types, since this aligns with this hypothesis that ACE-041 might have anti-tumour activity in virtually any tumour that has angiogenic activity, of tumour histology regardless. Additionally it is important to remember that while we’ve demonstrated significant activity with ACE-041 monotherapy in this study, we may expect to see a lot more efficacy in upcoming studies with ACE-041 used in combination with other therapies.’ Prof Sharma and his colleagues are planning further investigations of the protection and tolerability of the drug in an additional group of patients and hope to start stage II research of ACE-041 in 2011.Infection rates varied based on age and competition markedly, with African American kids at greatest risk. More than 18 % of the youngest African American kids evaluated were infected, with that number dropping to 7 % by the time they reached fifth grade. In contrast, infection prices in Hispanic and Caucasian children were significantly lower. The reason behind the significantly higher prevalence in African Us citizens is not clear. Related StoriesNew UCLA research looks at primary care medical house in reducing childrens' repeat appointments to hospitalsResistance to CD19 CAR T-cell therapy can be caused by CD19 splicing alterationsOutreach program raises completion of HPV vaccination series by teens in safety-net settingsCurrent treatment regimens for T.