This calculation was based on a simulation study in which the simulated data were analyzed using a three-parameter EMAX model. Upon this basis, we aimed to enroll 45 sufferers in the placebo group and in the 15-mg twice-daily tofacitinib group and 30 sufferers in each one of the other tofacitinib groups . Results Individual Characteristics A complete of 195 patients were assigned to a study group randomly, of whom 194 received a dosage of the study medication: 48 patients in the placebo group and 31, 33, 33, and 49 in the tofacitinib groups receiving 0.5 mg, 3 mg, 10 mg, and 15 mg twice daily, respectively.In the FISSION study, we determined a sample of 250 patients with HCV genotype two or three 3 in each study group would provide a power of more than 95 percent to determine the noninferiority of sofosbuvir and ribavirin, in comparison with ribavirin and peginterferon. We used two-sided testing at the 0.05 level in both scholarly studies. Multivariable logistic-regression analyses characterizing the relationship between a sustained virologic response and different prespecified demographic and baseline scientific characteristics had been performed. A stepwise selection process was used to recognize independent predictors of a sustained virologic response. Results Study Patients In the NEUTRINO research, of the 456 patients with HCV genotype 1, 4, 5, or 6 who were initially screened, 328 were enrolled, and 327 began treatment .