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Unfortunately, we were not able to study viable cells from the family in vitro due to logistical constraints. Th17 cells and their creation of interleukin-17 have already been shown to play a pivotal role in mucosal host defense against candidiasis in mice.56,57 Moreover, Eyerich et al. Reported decreased numbers of Th17 cells in two sporadic instances of chronic mucocutaneous candidiasis,58 but the role of these cells in individual antifungal immunity continues to be elusive. If having less Th17 cells and their cytokines were critical for the pathogenesis of mucosal candidiasis, one could speculate that in individuals with a low total CD4 count, such as for example in the low-CD4 syndrome, another rare principal immunodeficiency, or in patients with the acquired immunodeficiency syndrome, the lack of CD4 differentiation into Th17 cells is critical for maintaining the mucosal host defense against candida.